Association between newly identified serotonin transporter missense variants and chronic affective disorders: Molecular insights and potential therapeutic avenue
Jonatan Fullerton Støier, Jade Degrandmaison, Trine Nygaard Jørgensen, Thomas Sparsø, Henrik Berg Rasmussen, Vivek Kumar, Amy Hauck Newman, Randy D. Blakely, Thomas Werge, Ulrik Gether, Freja Herborg · FENS Forum 2024
Affective disorders, which can be categorized into depressive and bipolar disorders, represent a leading cause of disability worldwide. Despite their considerable prevalence, the intricate molecular and cellular mechanisms underlying these conditions remain elusive, mainly due to their complex etiologies and heterogeneous clinical presentations. Over the past years, the serotonergic system has emerged as a focal point in understanding the pathophysiological and therapeutic responses of affective disorders. Among the major regulators of this system, the serotonin transporter (SERT), which media
ePoster · Neuroscience