Topic: set-shifting task

Behavioral flexibility is the ability to adapt behavior when facing environmental changes. This function typically involves the cognitive circuitry of the basal ganglia, which receives inputs from frontal cortical areas. Here, we investigated the role of the orbitofrontal cortex (OFC) and its thalamic inputs in behavioral flexibility. This study combined behavioral approaches and in vivo electrophysiology in anesthetized rats. First, we assessed flexibility with a set-shifting task. This procedure alternates between visual discrimination rules and response discrimination rules. An individu