Increased GABAergic neurogenesis in human cortical organoids with schizophrenia-associated SETD1A mutations
Hilde Smeenk, Bas Lendemeijer, Mehrnoush Aghadavoud Jolfaei, Diana Rotaru, Sara Hijazi, Zhixiong Sun, Sander Markx, Bin Xu, Joseph A. Gogos, Steven A. Kushner, Femke M. S. de Vrij · FENS Forum 2024
Schizophrenia (SCZ) is a debilitating psychiatric disorder, affecting approximately 1% of the global population. Estimates of the heritability rate of SCZ range around 80%, suggesting a strong genetic component. Loss-of-function mutations in SETD1A have been linked to both SCZ risk and other neurodevelopmental phenotypes. SETD1A is involved in chromatin remodeling through its function as a H3K4 methyltransferase, but how SETD1A loss-of-function mutations lead to altered brain function remains unclear. In the present study, we aim to gain insight into functional consequences of reduced SETD1A f
ePoster · Neuroscience