Topic: SETDB1

Throughout the course of evolution, the human genome has integrated genetic material from ancient retroviral infections, which now constitute approximately 8% of its total DNA. Significant portion of these endogenous retroviruses (ERVs) are non-functional due to mutations and deletions. However, some of the more recently acquired families, such as HERV-K (HML-2), retain intact genes that are capable of producing viral proteins. ERVs play roles in various physiological processes that are beneficial or crucial for the host, including the development of the placenta, protection of neurons, and di