Topic: sEVs

Spinocerebellar ataxia type 2 (SCA2) is a rare neurodegenerative disorder characterized by cerebellar dysfunction and significant loss of Purkinje cells, with subsequent involvement of other brain regions, suggesting a potential disease-spreading mechanism. Our study sheds light on SCA2 pathogenesis by revealing the presence of mutant ATXN2 mRNA within small extracellular vesicles (sEVs). These sEVs demonstrate the ability to transport the mutant mRNA to recipient cells, leading to its translation and the formation of mutant protein aggregates, a neuropathological hallmark of SCA2.Additionally