Hypothalamic gene expression following early life and acute stress exposure in adulthood: Focus on sex differences
Michael Vencer Malaluan, Janssen M Kotah, Aniko Korosi · FENS Forum 2024
Early life stress (ELS) is linked to risks for later-life disorders with a sex bias (e.g., depression, obesity, and Alzheimer’s disease). It remains unclear whether such bias has early origins and if sex-dependent adaptations to ELS play a role. We focused on the hypothalamus, a crucial neuroendocrine stress axis (Hypothalamus-Pituitary-Adrenal axis) modulator, and studied gene expression profiles under control conditions and how ELS affects these long-term, and how sex and ELS impact the acute stress response.Mice underwent ELS by limited bedding and nesting from postnatal day (P) 2-9, then a
ePoster · Neuroscience