Differential expression of prefrontal cortex miRNAs involved in depression-related pathways
Lluis Miquel-Rio, Claudia Yanes, Elena Haro, Judith Jericó, J Javier Meana, Cristina Fornaguera, Javier de Diego-Adeliño, Analia Bortolozzi · FENS Forum 2024
Major depressive disorder (MDD) is a debilitating disorder whose etiology remains unclear. Small RNA molecules, such as microRNAs (miRNAs), have been implicated in MDD, where they display differential expression in the brain and periphery. Hence, numerous studies have identified altered gene expression and changes in anterior cingulate cortex (ACC) activity in MDD, which appear to be related to antidepressant treatment response. Here, we quantified miRNA expression by small RNA sequencing in the ventromedial prefrontal cortex (vmPFC) of individuals with MDD/suicide and healthy controls. miRNA
ePoster · Neuroscience