Behavioural hypersensitivity to CO2 is associated with increased engagement of the insula in subjects with high trait anxiety
Simone Sartori, Nino Kobakhidze, Francesca Silvagni, Claudia Schmuckermair, Arnau Ramos-Prats, Pawel Matulewicz, Sarah Gorkiewicz, Gaia Novarino, Francesco Ferraguti, Nicolas Singewald · FENS Forum 2024
Patients with an anxiety disorder often display aberrancies in sensing the internal state of the body. Interoception is activated for example by mild hypercapnia during CO2 inhalation due to homeostatic disturbances of the body eliciting anxiety and even panic-like behaviours across species. Yet, although altered interoception is increasingly recognized as an important component of anxiety disorders, its underlying neural mechanisms remain little understood. Here, we aimed to elucidate whether trait anxiety levels affect the engagement of the anxiety network in response to CO2 challenge. Mice
ePoster · Neuroscience