Western diet administration in aged mice results in sex-dependent cognitive and metabolic dysfunction: Preventive role of rosmarinic acid
Letizia Giona, Chiara Musillo, Michael Ristow, Kim Zarse, Karsten Siems, Sabrina Tait, Francesca Cirulli, Alessandra Berry · FENS Forum 2024
Unhealthy nutrition, such as that characterized by a westernized style, can lead to metabolic syndrome (MetS), a cluster of cardio-metabolic risk factors associated with increased incidence of cognitive dysfunction, reducing the quality of life during aging. By contrast, regular consumption of nutraceuticals may promote brain and metabolic health, with limited side effects. We investigated whether oral administration of the polyphenol rosmarinic acid (RA, 500mg/kg) might protect aged male and female C57BL/6N mice from cognitive decline and metabolic derangement upon western diet (WD, 5.28 kcal
ePoster · Neuroscience