A sexual dimorphic microglia response modulates visual cortex network activity after ketamine anesthesia
Alessandro Venturino, Ryan John A. Cubero, Marco Benevento, Mohammadamin Alamalhoda, Rouven Schulz, Karl Rössler, Thomas Czech, Gloria Colombo, Jake Yeung, Bosiljka Tasic, Mathias V. Schmidt, Sandra Siegert · FENS Forum 2024
Anesthetics induce a reversible coma-like state and alter the brain excitation. We showed that repeated exposure to ketamine causes the loss of the perineuronal nets (PNN) and reestablishes juvenile-like plasticity in the adult visual cortex (V1) (Venturino et al, 2021). Microglia enable the PNN dismantling and their depletion prevented this effect. In a side investigation, we observed that under acute ketamine exposure, microglia adapt in a sex-dependent manner. Thus, is there a sex-specific effect of how microglia modulate neuronal activity? Here, we show a sex-specific adaptation of the neu
ePoster · Neuroscience