Sex-specific and epigenetically mediated changes of CB1R expression in the medial prefrontal cortex in response to early life stress
Jörg Bock, Anna Portugalov, Mouna Maroun, Irit Akirav, Katharina Braun, Arijana Demaili · FENS Forum 2024
Early life stress (ELS) can induce long-term changes of brain functions and behavior, thus representing a significant risk factor for the development of mental disorders such as depression and anxiety. A brain system particularly affected by ELS is the endocannabinoid system, a critical regulator of socio-emotional behavior and the stress response. In a first study we showed that adult female rats exposed to ELS show significant changes in their behavioural phenotype, specifically depressive-like symptoms such as anhedonia and disturbed social behavior. These behavioral changes where parallele
ePoster · Neuroscience