Neurotoxicity of Cumyl-PINACA synthetic cannabinoid: Involvement of multiple cannabinoid receptors
Klara Bulc Rozman, Metoda Lipnik-Štangelj, Dušan Šuput, Miran Brvar, Damijana Mojca Jurič · FENS Forum 2024
Synthetic cannabinoids as potent recreational drugs disrupt the endocannabinoid system in the brain, leading to severe mental and behavioral consequences. Cumyl-PINACA or SGT-24 is a synthetic agonist designed to bind cannabinoid receptor 1 (CB1) with very high affinity, yet the molecular mechanisms underlying its central toxic effects are poorly understood.In this study, we investigated the response of rat cortical neurons and astrocytes to SGT-24 at nanomolar concentrations (0.1 - 1000 nM). The effects of SGT-24 were dose- and time-dependent, as well as cell-specific. In neurons, 10 nM SGT-2
ePoster · Neuroscience