Modeling and inference of brain functional connectivity networks in the Shank2 mouse model of autism using functional ultrasound
Ruben Wijnands, Justin Dauwels, Ines Serra, Pieter Kruizinga, Aleksandra Badura, Borbála Hunyadi · FENS Forum 2024
This study investigates brain functional network dynamics of freely behaving but head-fixed mice using functional ultrasound (fUS). Unlike traditional fMRI, fUS allows recording brain activity in awake, behaving mice without anesthesia. We established a pipeline for processing fUS data and applied it to behavioral mouse data from a preclinical model of autism carrying a Shank2 gene knockout mutation. The pipeline includes several pre-processing stages, a deconvolution-based method for investigating neuronal activity underlying the fUS signal, and an analysis using hidden Markov models (HMM) to
ePoster · Neuroscience