Topic: Shank3 KO mice

Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with social communication deficits, repetitive behaviors, and atypical sensory responses. Around 90% of the patients diagnosed with ASD experience atypical sensory events, with abnormal responses to tactile stimulation. However, the neurological underpinnings of tactile dysfunction in ASD are not yet understood. Using behavior and electrophysiological in vivo recordings, this work aims to promote a better understanding on tactile sensitivity and neuronal responses to glabrous skin tactile stimulation in Shank3 KO mouse