Effects of chronic treatment with extracted active ingredients from Chinese traditional medicine formula: Yueju on alleviating depression in animal models
Sonata Suk-yu Yau, Kai Le, Ping Wang, Jiaqi Li, Can Huang, Jiasui Yu, Gang Chen · FENS Forum 2024
Yueju, a Chinese traditional herbal medicine formula, has a rapid antidepressant action. We have previously identified two active ingredients from Yueju: two iridoids, geniposide (GM) and shanzhiside methyl ester (SM). Only co-treatment (GS) with GM (44 mg/kg) and SM (4.7 mg.kg) elicits synergistic rapid antidepressant action by activating polypeptide (PACAP) activity and its associated CaMKII–BDNF signalling the hippocampus. We further investigate whether chronic treatment with GM and SM are effective in eliciting antidepressant effects via enhancing hippocampal adult neurogenesis. Two mouse
ePoster · Neuroscience