Topic: sharp wave-ripples

We used dense (20 m site spacing) local field potential (LFP) and single unit recordings across all layers of the gRSC concurrent with CA1 LFP recordings in behaving mice to investigate circuit activity of high-frequency oscillations (HFOs) in theta and sharp wave-ripples (SWRs). By comparing HFOs occurring at times of SWRs (+/-50 ms) or during theta, we found using current-source density analysis that HFOs in different states are uniformly localized to layer 2/3 (L2/3) with current sources and sinks bridging the L1-L2/3 border. HFOs that occurred outside of SWR times where rhythmically locke

The hippocampal formation has been implicated in both cognitive functions as well as the sensing and control of endocrine states. To identify a candidate activity pattern which may link such disparate functions, we simultaneously measured electrophysiological activity from the hippocampus and interstitial glucose concentrations in the body of freely behaving rats. We found that clusters of sharp wave-ripples (SPW-Rs) recorded from both dorsal and ventral hippocampus reliably predicted a decrease in peripheral glucose concentrations within ~10 minutes. This correlation was less dependent on cir

Sharp wave-ripples (SPW-Rs) are widely studied oscillatory patterns observed during sleep and awake immobility in the hippocampal formation of most mammals [Buzsáki, 2015]. During SPW-Rs behavioral sequences are replayed compressed in time [Wilson & McNaughton, 1994; Diba & Buzsáki, 2007], which led to the hypothesis that they are mediating memory transfer from the hippocampus to the neocortex [Buzsáki, 1989]. SPW-Rs can be internally generated in the highly recurrent CA3 network [Maier et al., 2003], but their incidence during sleep is affected by slow oscillations in the cortex [Sirota et al