Topic: Short chain fatty acids

Alzheimer’s disease (AD), like other neurodegenerative disorders (NDs), is associated with chronic inflammation of the central nervous system via astrocyte and microglia activation. Previous work from our lab described Secreted Frizzled-related protein 1 (SFRP1) as a novel player in AD pathogenesis and neuro-inflammatory chronicity by modulating astrocyte-microglia crosstalk. The gut microbiome has increasingly attracted attention for its possible contribution to NDs through the gut-brain axis. In fact, microbiota-derived metabolites, such as short chain fatty acids (SCFA), have been related t