Pubertal immune challenge differentially modulates LPS-induced molecular and behavioural sequelae in adult male and female mice
Cristina Benatti, Ylenia Toscano, Veronica Rivi, Giovanna Rigillo, Miriam Ciani, Silvia Alboni, Fabio Tascedda, Johanna Blom · FENS Forum 2024
Adolescence, a critical stage of development characterized by increased neuroplasticity, is marked by a significant risk for the onset of psychiatric disorders. Inflammatory events during this period may increase the risk of developing psychiatric disorders, with tryptophan metabolism playing a potential role in this process.Our goal was to investigate whether exposure to lipopolysaccharide (LPS) during adolescence impacts emotional behaviour and the inflammatory response in adult animals in a sex-specific manner. Male and female C57BL6J mice were injected at PND36 with LPS (0.1 mg/kg i.p.) or
ePoster · Neuroscience