Topic: signaling molecules

Astrocytes were seen for a long time as supportive cells in the central nervous system. However, evidence points to the pivotal role of these cells in brain function, including the modulation of synaptic transmission. Astrocytes express neurotransmitter receptors at the cellular membrane, whose activation may cause somatic calcium elevations and consequently release signaling molecules in the synaptic cleft. The impact of astrocytic signaling in the modulation of neuronal circuits and behavior is still poorly understood. Social behavior results from a complex interaction between brain regions.