Topic: simple spike activity

The cerebellum is critical for coordinating movement, and during locomotion it is particularly important for interlimb coordination. Decades of recordings have consistently shown that cerebellar Purkinje cell modulation is broadly correlated with the locomotor stride cycle. However, much of the firing rate variability has remained unexplained, and it is not yet clear how Purkinje cell population activity could be read out to control whole-body coordination. Here, we performed cell-attached recordings of Purkinje cell simple spike activity in head-fixed mice locomoting for liquid rewards, toget