Oligodendrocytes produce amyloid beta, and blocking its production restores neuronal function in an Alzheimer's mouse model in vivo
Rikesh Rajani, Robert Ellingford, Mariam Hellmuth, Samuel Harris, Orjona Taso, David Graykowski, Francesca Lam, Charles Arber, Emre Fertan, John Danial, David Klenerman, Robert Vassar, Selina Wray, Carlo Sala Frigerio, Marc Aurel Busche · FENS Forum 2024
The reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer’s Disease (AD), but an underlying assumption that neurons are the main source of pathogenic Aβ remains untested. Here we show that oligodendrocytes produce significant amounts of Aβ, which in turn promotes abnormal neuronal hyperactivity in AD. Initially, we assessed publicly available single cell RNA-sequencing and proteomics databases and showed that oligodendrocytes express all the components required to produce Aβ. By employing RNAscope in situ hybridisation we revealed that the brains of AD patients ha
ePoster · Neuroscience