Temporal dynamics of neuronal excitability in the lateral amygdala mediates allocation to an engram supporting conditioned fear memory
Annelies Hoorn, Sungmo Park, Asim Rashid, Paul W. Frankland, Sheena A. Josselyn · FENS Forum 2024
Memories are encoded by ensembles of neurons (engrams) that are active during learning. Within a given brain region, eligible neurons compete for allocation to an engram and neurons with increased excitability at the time of training are likely to be allocated to the engram. Previous findings show that neurons with increased excitability during training also have increased excitability for ~6h. Here, we examined the temporal dynamics of neuronal excitability important for memory allocation. We focused on the lateral amygdala (LA) and cued fear memory. We expressed both an excitatory and inhibi
ePoster · Neuroscience