Novel insights in oligodendroglia as a key cell type in Parkinson’s disease
Juan Manuel Barba Reyes, Lisbeth Harder, Mónica Díez Salguero, Sergio Marco Salas, Mats Nilsson, Alberto Serrano Pozo, Bradley Hyman, Ana Belén Muñoz Manchado · FENS Forum 2024
Parkinson’s disease (PD) is characterized by the selective loss of dopaminergic neurons in the Substantia Nigra and Lewy body formation, resulting in a progressive neurodegenerative disorder with movement defects. The impairment of dopaminergic innervation in PD hinders the two main projection systems from the dorsal striatum (Putamen, Pu, and Caudate Nucleus, CN) from effectively responding to cortical and thalamic signals.A potential role of Oligodendrocytes (OLs) in PD was pointed out by recent works describing GWAS PD variants associated with OLs (Bryois et al, Nat Genet, 2020), PD genes e
ePoster · Neuroscience