Human iPSC-derived cell grafts promote functional recovery by molecular interaction with stroke-injured brain
Rebecca Weber, Beatriz Achón Buil, Nora Rentsch, Patrick Perron, Allison Bosworth, Mingzi Zhang, Kassandra Kisler, Chantal Bodemann, Kathrin Zürcher, Daniela Uhr, Siri Peter, Melanie Generali, Simon Hoerstrup, Roger Nitsch, Berislav Zlokovic, Christian Tackenberg, Ruslan Rust · FENS Forum 2024
Stroke is a leading cause of disability and death due to the brain’s limited ability to regenerate damaged circuits. Induced pluripotent stem cell (iPSC)-based therapies are emerging as a promising therapeutic approach for stroke recovery. Here, we demonstrate that local transplantation of GMP-compatible iPSC-derived neural progenitor cells (NPCs) improve long-term recovery-associated brain tissue responses and reduce neurological deficits after cerebral ischemia in mice. Using in vivo imaging and post-mortem histology, we showed long-term graft survival over the course of five weeks and prefe
ePoster · Neuroscience