Transient galanin expression modulates peripheral-to-central connectivity in the somatosensory thalamus during whisker development in mice
Zsofia Hevesi, Evgenii O. Tretiakov, Tomas Hökfelt, Tibor Harkany · FENS Forum 2024
The significance of transient neuropeptide expression during postnatal brain development is unknown. Here, we show that galanin expression in the ventrobasal thalamus of infant mice coincides with whisker map development and modulates subcortical circuit wiring. Time-resolved neuroanatomy and single-nucleus RNA-seq identified complementary galanin (Gal) and galanin receptor 1 (Galr1) expression in the ventrobasal thalamus and the principal sensory nucleus of the trigeminal nerve (Pr5), respectively. Somatodendritic galanin release from the ventrobasal thalamus was time-locked to the first post
ePoster · Neuroscience