Topic: single-unit clusters

The availability of high-density electrophysiology is transforming systems neuroscience and enables virtually any experimental lab to simultaneously acquire activity from hundreds of neurons throughout the brain. However, extracting single-cell activity from the resulting large datasets remains a major challenge: different experimental settings introduce various sources of contaminating noise, and even optimized spike-sorting algorithms still require manual evaluation of the resulting spike clusters. Establishing a pre-processing pipeline and manual evaluation requires expert knowledge and is