Targeting clusterin for therapeutic intervention in gliomas
Pinky Sultana, Ondrej Honc, Zdenek Hodny, Jiri Novotny · FENS Forum 2024
Introduction:The glycoprotein clusterin (CLU) plays a pivotal role in vital cellular functions, including cell proliferation and DNA damage repair. Its frequent overexpression in tumor cells, particularly in gliomas, positions it as a promising therapeutic target. This study aims to investigate the impact of CLU dysregulation on glioma cell lines and explore its therapeutic potential. Methods:Two human astrocytic cell lines, CCF-STTG1 astrocytoma cells, and SV-40 immortalized normal human astrocytes, were utilized in our investigation. CLU expression was suppressed using transient siRNA transf
ePoster · Neuroscience