Palmitic acid induces posttranslational modifications of tau protein in Alzheimer’s disease-related epitopes and increases intraneuronal tau levels
Valeria Melissa García Cruz, Clorinda Arias · FENS Forum 2024
Alzheimer Disease (AD), the most common neurodegenerative disease in elderly has been recently associated with the consumption of high fat diets in which Palmitic Acid (PA) is one of the principal components. Recent studies have shown that neurons can metabolize PA through β-oxidation leading to an increase in ATP levels, decrease in NAD+ concentration and reduced Sirtuin 1 expression and activity. These processes converge on the regulation of different signaling pathways that could regulate and impact posttranslational modifications (PTMs) of tau protein. To elucidate the kinases involved in
ePoster · Neuroscience