D1 receptors in the nucleus accumbens regulate social fear memory processing
Fernando Castillo Diaz, Sophie Schmid, Anna Bludau, Inga Neumann · FENS Forum 2024
Interactions between conspecifics trigger the release of dopamine (DA), primarily from the ventral tegmental area (VTA) into the Nucleus Accumbens (NAc), promoting pleasure and positive reinforcement. Disruptions in DA levels can impact social motivation, potentially decreasing responsiveness to social reward and increasing the risk for social anxiety disorder.Using the social fear conditioning (SFC) paradigm, we investigated how DA regulates social motivation and its role in processing social fear. Our approach combined behavioural pharmacology and molecular techniques focusing on the VTA and
ePoster · Neuroscience