Cuproptosis, copper homeostasis, and management in intracerebral haemorrhage (ICH)
Tsz Ching Alexia Ng, Cuiting Zhang, Karrie Mei Yee Kiang, Gilberto Ka Kit Leung · FENS Forum 2024
Intracerebral haemorrhage (ICH) is a subtype of stroke, characterised by bleeding into brainparenchyma. In 2022, studies discovered a novel mechanism of cell death, cuproptosis, referring to copper-induced cell death. In ICH, disruption of blood-brain barrier followed by infiltration of copper from plasma into brain, results in copper overload and cuproptosis. Oligomerization of Dihydrolipoamide S-Acetyltransferase (DLAT) has been identified as a hallmark of cuproptosis. We aim to study whether ICH would induce cuproptosis as a result of DLAT accumulation. ICH was induced in C57BL/6 mice by c
ePoster · Neuroscience