Topic: Sleep-states

The metabotropic glutamate receptor, mGlu5, plays a critical role in the persistency of hippocampal long-term potentiation (LTP), long-term depression (LTD) as well as hippocampus-dependent associative learning and memory (doi: 10.3390/cells11213352). Although well-studied, the majority of investigations as to the role of mGlu5 in these processes in rodents has been done during the light cycle that amounts to the resting phase of rodent species. Sleep-states are regulated by mGlu5 (doi: 10.3390/cells12131761) suggesting that its contribution to hippocampal information processing and storage ma