Topic: sleep-wake history

Background: In temporal lobe epilepsy, seizures tend to occur at preferential times of the day. This timing of seizures may result from the sleep-wake history (process S) and/or from the circadian rhythm (process C). We aimed at disentangling their contributions to timing limbic seizures in the hippocampal kainic acid mouse model. Methods: Using 16 depth-electrodes, we recorded limbic seizures in epileptic mice (n=24) exposed to different chronobiological paradigms over months: 1)12h:12h light-dark cycle (LD), 2) gentle sleep deprivation (GSD), 3) continuous dim red light (DD), 4) continuous l