Topic: Slit1a

Retinal ganglion cell (RGC) axons have become a paradigm to understand axon growth and guidance in vivo, with many known signals known to be involved along the trajectory followed by these axons to reach their target at the optic tectum. Among these, Slit-Robo signaling appears as one of the main regulators of axon crossing at the optic chiasm. In the zebrafish, a species with no stereoscopic vision and complete crossing of all optic fibers, Robo2 expressed by RGCs was shown to be essential in regulating correct axon midline crossing and bundling to form the optic tracts. We recently reported