A pre-cerebellar brainstem integrator implements self-location memory and enables positional homeostasis
En Yang, Maarten Zwart, Benjamin James, Mikail Rubinov, Ziqiang Wei, Sujatha Narayan, Nikita Vladimirov, Brett Mensh, James Fitzgerald, Misha Ahrens · COSYNE 2023
To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation (1,2), but it is unknown if positional representations exist in more ancient brain regions, how they arise from integrated self-motion, and by what pathways they control locomotion. Here, in a head-fixed, fictive-swimming, virtual-reality preparation (3), we exposed larval zebrafish to a variety of involuntary displacements. They tracked these displacements and, many seconds later, moved toward their earlier location through c
Sun, Mar 12, 2023