Amyloid beta 1-42 and alpha-synuclein proteins: Effects on transcription factor expression
Pelin Sordu, Merve Alaylıoğlu, Zuhal Yurttaş, Tugay Çamoğlu, Büşra Şengül-Yediel, Ebru Keskin, Duygu Gezen-Ak, Erdinç Dursun · FENS Forum 2024
Previous studies provided that Aβ1-42 peptide, a pathological component of Alzheimer's disease (AD), and α-synuclein, the major protein of Lewy bodies in Parkinson's disease (PD), may interact with transcription factors and affect gene transcription. Researchers have revealed that Aβ1-42 can be found in the nucleus, interact with DNA, and change the expression of many genes. It is known that α-synuclein functions as a transcription factor that binds to nuclear DNA and modulates the expression of many genes. Our study aims to investigate whether these peptides directly affect the expression of
ePoster · Neuroscience