The brain sphingolipid system in schizophrenia and its treatment
Christian Müller, Christiane Mühle, Fabian Schumacher, Liubov Kalinichenko, Peter Gmeiner, Christian Alzheimer, Stephan von Hörsten, Erich Gulbins, Johannes Kornhuber, Hee Kyung Jin, Jae-sung Bae, Anbarasu Lourdusamy, Daria Chestnykh · FENS Forum 2024
Schizophrenia is a highly heterogeneous psychiatric disorder, which is elicited by multiple genetic and non-genetic factors. It remains insufficiently treatable with the current pharmaceutical approaches. In this study, we describe a new pathological mechanism and identify a new pharmacological treatment target with the use of a recently introduced ligand for it. An initial analysis of human gene polymorphisms and brain gene expression in schizophrenia patients identified an association of Smpd1 and Smpd3 genes coding for acid- (ASM) and neutral sphingomyelinase (NSM). In a rat model of amphet
ePoster · Neuroscience