Topic: Snudda

The substantia nigra pars reticulata (SNr) is a primary output for basal ganglia signalling. It plays an important role in motor control, integrating inputs from upstream structures in the basal ganglia, before sending organised projections to a wide range of targets in the midbrain, brainstem and thalamus. Here we present a detailed in silico model of the mouse SNr, including its afferent inputs. The electrophysiological and morphological properties of SNr neurons are characterised in acute brain slices via whole cell patch-clamp and morphological reconstruction. Using reconstructed morpholog