Amygdala neurons differentiating unfamiliar and familiar mice to establish social novelty preferences
Shingo Soya, Koji Toda, Katsuyasu Sakurai, Yoan Cherasse, Yuki Saito, Manabu Abe, Sakimura Kenji, Takeshi Sakurai · FENS Forum 2024
Despite its critical importance to social animals, the mechanisms underlying the establishment of new social interactions remain largely unknown. We identified a role for neurons expressing neuropeptide B/W receptor-1 (NPBWR1) in the central amygdala (CeANpbwr1 neurons) in this process. CeANpbwr1 neurons were activated only during physical interactions with unfamiliar mice, but not with familiar mice. Manipulations of the neuronal circuit comprising CeANpbwr1 neurons suggested that this excitation was essential for sustaining physical interactions with novel conspecifics. Remarkably, stimulati
ePoster · Neuroscience