Effect of ENERGI in valproate-induced animal with autism spectrum disorder
Chi-Chun Wu, Ming-Chia Chu, Chi-Wei Lee, Hui-Ching Lin · FENS Forum 2024
Autism spectrum disorder (ASD) is a neurodevelopmental disorder which core features are social communication impairments and repetitive behaviors. AMP activated protein kinase (AMPK) is a Ser/Thr kinase which is critical in synaptic plasticity function. Until now, there are no effective medications to improve core symptoms for ASD. Some reports showed that AMPK expresses abnormally in autism model. ENERGI is a purine compound, activating AMPK to improve self-healing by increasing ATP. ENERGI has been used in many diseases include neurodegenerative diseases. Hence, we aimed to identify efficacy
ePoster · Neuroscience