Chemogenetic elevation of hippocampal excitability unmasks latent ASD risks in non-autistic mice differing in hippocampal AMBRA1 expression and/or sex
Margherita De Introna, Paraskevi Krashia, Annamaria Sabetta, Francesca Stabile, Livia La Barbera, Annalisa Nobili, Marcello D’Amelio, Francesco Cecconi, Martine Ammassari-Teule, Annabella Pignataro · FENS Forum 2024
Among the genomic alterations identified as risk factors in Autism Spectrum Disorders (ASD), haploinsufficiency of AMBRA1 (Activating Molecule in Beclin1-Regulated Autophagy) triggers an ASD phenotype associated with hippocampal hyperexcitability exclusively in the female sex. Remarkably, AMBRA1 protein is constitutively more expressed in the hippocampus of wild-type (Wt) females than males. However, being more decreased by AMBRA1 deficiency in the female than the male sex, it results comparably expressed in the hippocampus of autistic females and non-autistic males. In this study, we verified
ePoster · Neuroscience