ePoster · Neuroscience
Differential neural oscillation dynamics in basolateral amygdala and medial prefrontal cortex induced by allopregnanolone and diazepam during social behavior
Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Keiko Takasu, Koichi Ogawa · FENS Forum 2024
Neuroactive steroids such as allopregnanolone that act as a positive allosteric modulator of synaptic and extrasynaptic δ-subunit-containing GABAA receptors, has shown antidepressant effects on depressive symptoms in both clinical and preclinical studies. However, the neuronal dynamics associated with these effects are still unknown. In the present study, we discovered that allopregnanolone, but not the benzodiazepine diazepam, has antidepressant-like effects in the social interaction test (SIT) of social defeat stress (SDS) model mice by decreasing intervals of repetitive social interaction (