Activation of somatostatin interneurons in the medial amygdala reverses long-term aggressive behavior associated with early-life stress in male mice
Aroa Mañas-Ojeda, José Hidalgo-Cortés, Clara García-Mompó, Mohamed Aly Zahran, Isis Gil-Miravet, Francisco E. Olucha-Bordonau, Ramón Guirado, Esther Castillo-Gómez · FENS Forum 2024
Early postnatal development is a critical period for the configuration of neural networks that support emotional and socioaffective behaviors. In this sense, children raised in stressful environments are at high risk of developing maladaptive behaviors immediately or later in life, including antisocial and aggressive behaviors. However, the neurobiological bases of such phenomena remain poorly understood. Here, we showed that, in the long-term, maternal separation with early weaning (MSEW) decreased the density of somatostatin (SST) interneurons in the basolateral amygdala (BLA) of females and
ePoster · Neuroscience