The knocking-down of the restrictive element 1-silencing transcription factor (REST) improves symptoms and limits motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis
Natascia Guida, Valeria Valsecchi, Serenella Anzilotti, Ornella Cuomo, Luca Sanguigno, Pignataro Giuseppe, Lucio Annunziato, Luigi Formisano · FENS Forum 2024
The restrictive element-1 silencing transcription factor (REST) is a transcriptional repressor which acts via epigenetic remodeling to silence numerous target genes. Emerging evidence indicates that REST is a master regulator of neuron-specific genes, not only in neurogenesis and neuronal differentiation, but also in differentiated neurons during postnatal brain development, where it plays a role in fine-tuning of genes involved in synaptic plasticity, and in normal aging, where it promotes neuroprotection by repressing genes involved in oxidative stress and dementia. However, un aberrant REST
ePoster · Neuroscience