Aging-associated weakening of the action potential in fast-spiking interneurons in the human neocortex
Adam Tiszlavicz, Viktor Szegedi, Szabina Furdan, Abdennour Douida, Emoke Bakos, Pal Barzo, Gabor Tamas, Attila Szucs · FENS Forum 2024
Aging is associated with the slowdown of neuronal processing and cognitive performance in the brain; however, the exact cellular mechanisms behind this deterioration in humans are poorly elucidated. Recordings in human acute brain slices prepared from tissue resected during brain surgery enable the investigation of neuronal changes with age. Although neocortical fast-spiking cells are widely implicated in neuronal network activities underlying cognitive processes, they are vulnerable to neurodegeneration. Herein, we analyzed the electrical properties of 147 fast-spiking interneurons in neocort
ePoster · Neuroscience