Topic: SOM+ neurons

The posterior insular cortex (pInsCx) is a multimodal hub processing sensory information and aversive states. However, little is known about how specific inhibitory interneurons in the pInsCx code for fear-learning-related stimuli. Here, we performed longitudinal in-vivo Ca2+ imaging in the pInsCx during a three-day fear learning protocol with a miniature microscope; GCaMP6m was expressed in either PV+, or SOM+, or VIP+ interneurons, or in CaMKII+ (principal) neurons. We observed that positive US responses were more common in interneurons (~ 50%) than in principal neurons (~ 13%). There were v