SorCS2 protects astrocytes from amyloid beta (Ab)-induced stress by modulating p75 NTR signaling
Tomasz Obrębski, Ewelina Ziemlińska, Vannesa Schmidt, Thomas E. Wilnow, Anna Malik · FENS Forum 2024
SorCS2 is a mammalian sorting receptor that is induced in astrocytes after stroke to support tissue regeneration (Malik et al., Glia 2020). It has been shown that SNP variants of SORCS2 have epistatic effects on Alzheimer’s disease (AD) risk (Reitz et al., Translational Psychiatry 2013), and that SorCS2 deletion in the AD mouse model causes decline in astrocyte number accompanied by a profound increase in toxic amyloid beta (Ab) levels (Network Glia Conference 2023, #341). These observations suggest that astrocyte-expressed SorCS2 may play a protective role not only after stroke, but also in A
ePoster · Neuroscience