Topic: Sorting Nexin 27

Sorting Nexin 27 (SNX27) is a brain-enriched endosome-associated cargo adaptor crucial for cognitive and reward processing and implicated in various neurological conditions. However, its precise role in the nervous system remains elusive. We conducted comprehensive behavioral characterization of SNX27+/- mice, as the KO is not viable, covering motor, cognitive, and emotional aspects. Leveraging recent insights into SNX27's involvement in cellular stress signaling, we also investigated SNX27-stress interplay using a Caenorhabditis elegans Δsnx-27 mutant and wild-type rodents submitted to stress