Topic: sound stimuli

Sounds are represented in the mouse auditory cortex in the form of a representational map, in which the similarity of global activity patterns elicited by a pair of sounds encodes their perceptual relationship. Interestingly, sensory processing in cortex is generally robust despite loss of neurons during aging, and even the accelerated loss during prodromal phases of neurodegeneration. Here, we probed the robustness of the representational map against the permanent removal of specific neurons and tested in how far its structure is stabilized by homeostatic network mechanisms. We combined longi