The control of stem cell quiescence in early postnatal dentate gyrus is essential for establishing long-lasting adult hippocampal neurogenesis
Paula Tirado Melendro, Cristina Medina-Menéndez, Lingling Li, Pilar Rodríguez-Martín, Elena Melgarejo, Mario Díaz, Aixa V. Morales · FENS Forum 2024
During embryonic and postnatal development of the dentate gyrus (DG), neural stem cells (NSCs) proliferate, migrate and generate mature granule neurons. Unlike other brain regions, NSCs remain in the adult DG, mostly in a state of deep quiescence, with the ability to re-enter cell cycle and generate new neurons throughout life. The transitions back and forward from a proliferative state to a temporal shallow quiescence or primed state ensure the maintenance of stem cell population. However, it is unclear when and how adult NSCs acquire quiescence sub-states during development. Recently, we hav
ePoster · Neuroscience