Impaired modulation of trigeminal caudal nucleus somatosensory responses by the locus coeruleus in a mouse model of diabetes: Participation of GABAergic and glycinergic neurons
Alberto Mesa-Lombardo, Nuria Garcia-Magro, Yasmina B Martin, Ángel Núñez Molina · FENS Forum 2024
The trigeminal system plays a crucial role in processing somatosensory information, and its modulation is crucial for maintaining sensory homeostasis. This study investigates the inhibitory modulation of trigeminal somatosensory responses by the locus coeruleus (LC), a key brainstem nucleus that plays a critical role in many cognitive and physiological functions. Previous electrophysiological investigations have revealed a diminished ability of the LC to inhibit somatosensory responses in the caudal nucleus of the trigeminal nerve (Sp5C) of diabetic mice. The administration of noradrenaline ag
ePoster · Neuroscience